Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on the Host Response to Influenza A Viral Infection

Response to Influenza A Viral Infection (COX-1) and COX-2 Deficiency on the Host Contrasting Effects of Cyclooxygenase-1

Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice

BACKGROUND We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice. METHODOLOGY/PRINCIPAL FINDINGS We investigated the effects of COX-1 and COX-2 inhibitors in influenza A viral infection. Mice were given a COX-1 inhibitor (SC-560)...

Tumorigenesis Epidermal Differentiation and Reduces Mouse Skin Deficiency of Either Cyclooxygenase (COX)-1 or COX-2 Alters

Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis in humans and in rodents. These drugs are believed to act by inhibiting one or both of the known isoforms of cyclooxygenase (COX). However, COX-2, and not COX-1, is the isoform most frequently reported to have a key role in tumor development. Here we report that homozygous deficiency of either COX-1 or COX-2 redu...

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.

Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis in humans and in rodents. These drugs are believed to act by inhibiting one or both of the known isoforms of cyclooxygenase (COX). However, COX-2, and not COX-1, is the isoform most frequently reported to have a key role in tumor development. Here we report that homozygous deficiency of either COX-1 or COX-2 redu...

Clinical Implications of Cyclooxygenase Enzymes: COX-1/COX-2 Role of the New NSAIDs.

Professor John Vane won the Nobel Prize for elucidating the mechanism of action of aspirin. He reported that this was accomplished by blocking the enzyme called cyclooxygenase (COX-1) that was responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins liberated from arachidonic acid by cyclooxygenase are short-lived substances that act as local hormones (autocoids) imp...